Put the weight of 200 mg on the pan and note the 10 measurements in the Template of measurement uncertainty test (Annexure -2). Pick up the weight with a forceps, place it carefully on the pan. Ensure that nothing comes in contact with the analytical balance. Links to PubMed are also available for Selected References. 0000020991 00000 n Place a single weight that weighs about 1/3 to 1/2 of the balance weighing capacity successively in the positions shown in Figure 1 (center, right-front, right-rear, left-rear, left-front, and center) and record the measurement value at each position. Where precision is paramount an error of 0.001 gram or smaller can be significant when strict regulations apply. Minimum and Maximum limit calculated as above for all weights. – Calibrate and, if necessary, adjust the balance regularly prior to use. 0000422565 00000 n Analytical balances represent the most accurate weighing standard for general use. i am trying to weigh my stuff on a analytical balance ... roughly proportional to the weight. Weighing scale for a baby includes a ruler for height measurement. 0000016482 00000 n Microbalances— Proceed as directed for Analytical Balances, but use a check-weight appropriate for the particular balance. – Use an ionizing blower to neutralize static electricity as needed. 0000017828 00000 n Place the weight in the center of the balance pan to eliminate the corner-weighing difference. Analytical balance errors can arise when the instrument records an inaccurate weight of samples owing to internal and external influences unknown to the operator or … weighing pan. You'll be learning to use two balances: a standard laboratory balance and an analytical balance. Remove powder if any, from inside the balance using soft nylon brush & wipe with clean cotton balls. This temperature difference will become a weighing error. Make sure the balance is “smart” enough not to begin calibrating in the middle of a weighing. SOP for Maintenance of Laboratory Instruments. A strong charge on filter paper will attract particulates. Electrostatic force can cause movement in small objects, including the weigh pan of an analytical balance. Transferred the approximate required quantity of semi-solid material to the receiver (by touching the inner surface of the receiver ) with the help of a capillary tube or spatula. Check that balance is exactly in a horizontal position, compensate it if any minor unevenness in its location by turning two leveling feet at the rear of the balance housing until the air bubble is in the center of the leveling control (internal circle). Many chemicals, such as salts are corrosive, and material of this nature should not be spilled on the balance pan or inside the balance housing. Where “ d” is the scale interval (readability ) of the balance. shall be reprinted and implemented including following. Accurate Reading on an analytical Balance The features of an electronic . In simple terms, digital analytical balance errors arise when the instrument inaccurately records the weight of the sample due to influences that can occur without the operator’s knowledge, or because of poor weighing practices. �y,..���z9�ɠ��^e3�W I&%%� Place the empty receiver on the balance in the center of the pan and press the appropriate tare (Zero) key on the balance (On stabilization of indicator). To do this you use a balance. Exercise caution when using a magnetic stirring bar. Uncertainty of a measurement result is a major issue in all fields of measurement. Analytical balances are accurate and actual equipment used to evaluate public. NIST             :  National Institute of Science and Technology. The analyst shall always use the calibrated weight box for calibration purposes. Before weighing or calibration, the balance should exactly in a horizontal position (check the level indicator, which should be in the center). If possible, Carry out all tests with a single test weight in order to minimize handling errors, but multiple test weights are permitted. Tare the balance (On stabilization of indicator), place the sample container on the balance in the center of the pan in a suitable container (bottle, tube, transfer pipette or syringe) and record the weight (On stabilization of indicator). Note- Do not change the set tare of the balance between these two weighings. The friction can create static electricity which can lead to considerable errors and discrepancies in weighing measurements ranging up to dozens of milligrams. If any unevenness is observed in its location. – To avoid having to warm up the balance again, leave it in standby mode rather than disconnect it from power. Mrs. Janki Singh is professional pharmaceuticals blogger, Founder and Author of Pharma Beginners, She has rich experience in pharmaceutical field. 0000410586 00000 n On stabilization of indicator record the displayed weight (Display weight shall be printed and keep with the raw data ) and transfer the glass coverslip directly into the receiver. If necessary, turn on the power, and allow the balance to equilibrate for at least 30 minutes before proceeding with the calibration. Place the balance on a solid weighing table. Put the weight 200 g on the pan and record the weight in Annexure-2. Full text Full text is available as a scanned copy of the original print version. Janki Singh is experienced in Pharmaceuticals, author and founder of Pharma Beginners, an ultimate pharmaceutical blogging platform. Carry out the Sensitivity by using 200 g weights. 0000585061 00000 n The field component will attract or repulse particulates. 0000003724 00000 n Ms. In the event of a spill re-qualification of balance may require, depending on the nature of the spill. The weight class chosen for the calibration should be such that the tolerance of the weights used does not exceed 0.1% of the amount weighed. 0000002443 00000 n This peril is repeated each time a transfer is attempted. In addition to purchasing a high-quality analytical balance, it is essential to use and maintain your analytical balance correctly. Place the empty butter paper / or receiver on the balance in the center of the pan, and press the appropriate tare (Zero) key on the balance (On stabilization of indicator). Similarly, Reprint Annexure -2 and implemented including the following. 0000422954 00000 n Problem: Magnetic materials in samples or containers, such as nickel, iron, steel, etc., particularly tin cans) generate force fields that act on the weighing pan and weighing chamber. Correct it by turning leveling feet until the level bubble is in the center of the indicator. Locate the analytical balances. The analytical balance is used to measure the mass of objects and chemicals until the 0.0001 gram accurately and precisely. Adjust the leveling feet to level the balance. weighing materials directly on the balance pan, always weigh the chemicals in or on something--a weighing dish, a beaker, or a piece of folded paper. The difference between the two weights represents the transferred material weight. �������д 1. The reason for this is that when the sample's temperature is higher than the room temperature, a layer of warmer air is created around the sample, and a slight upward air current is created. On the other hand, consistent errors in results can lead to a loss of equipment investment and also jeopardize compliance with industry standards. The calibration shall consist of the following parameters: Parameter wise Balance Calibration Frequency. Also read: SOP for Audit Trail Review and Privilege Policy, (Note: The  above mentioned general notes and precaution are applicable to all the analytical balance available in the Quality control department ). 0000002520 00000 n Wait till the message ‘cal done’ is displayed and Take the print out . Topics include To guarantee the accuracy of an analytical weighing balance over time, avoid an erroneous outcome in the future, and eliminate the chances of recurrence of the same problem, lab professionals should exercise the steps outlined below. Clean up balance base / pan using soft brush. Many factors can influence the performance of an analytical laboratory balance. 0000410046 00000 n balance in subsequent use will promote the reliability of your weighing results. Weighing is a critical step in any chemical laboratory and analytical methods. Some include: Temperature; Vibrations; Air drafts; Chemical reactions; Uncalibrated scales; Magnets; User error; Improper grounding; Slope; Inappropriate handling of the sample; Weighing of samples is an important part of analytical determinations. 0000408847 00000 n Email: © Copyright - Pharma Beginners designed by, Operation and Calibration of Analytical Balance, SOP for Analytical Balance: Operation and Calibration. The usual maximum capacity for the analytical balance is 110 g. 6) Always CARE for the balance. This is often the most time-consuming activity, and weighing errors at this stage can result in a loss of both time and money. The traditional scale consists of two plates or bowls suspended at equal distances from a fulcrum. 3. (adsbygoogle = window.adsbygoogle || []).push({});Standard Operating Procedure (SOP) for operation and calibration of analytical balances. This SOP is applicable to the analytical balances for operation and calibration of balances in the Quality Control Department. Do not overload the balance pan more than the capacity of the balance. Micro Balance – Operation and Calibration SOP, SOP for Audit Trail Review and Privilege Policy, Purified Water Loop – Operation & Maintenance SOP, Operation and Calibration of pH Meter - Pharma Beginners, Batch Processing - SOP & General Check Points - Pharma Beginners, SOP for Handling of Out of Calibration (OOC) - Pharma Beginners, SOP for Operation and Calibration of UV Cabinet - Pharma Beginners. The determination of mass is a fundamental component in quantitative analysis, and weighing accuracy is an important factor for most applications. ... Analytical Balance Calibration . %PDF-1.4 %���� Record the weight and transfer the weighed material to the final flask or beaker as per requirements, Then reweigh the original weighing butter paper / or receiver by placing it in the same position on the pan. Weighing is a critical step in any chemical laboratory and analytical methods. As if warm samples weighed then apparent weight is smaller than the true weight because of heat convention. Let’s see how you can maintain the analytical balance. Close the sliding door, press on enter key of the printer. The analyst shall update the calibration status label and make an entry in the instrument usage log book. If possible, Carry out all tests with a single test weight in order to minimize handling errors, but multiple test weights are permitted. Work room should be clean and dry 2. Transfer approximate required quantity of semi-solid material to the glass coverslip with the help of a capillary tube or spatula. Check the power supply of balance. Place the empty receiver (In case of material is highly volatile, add some amount of diluent) on the balance in the center of the pan and press the appropriate tare (Zero) key on the balance (On stabilization of indicator). In the next step it is important to remember that, unless the balance is checked before each weighing operation is performed, errors can easily occur, resulting in faulty analytical data. For example, a 100-mg check-weight might be selected for a balance that has a load limit of 150 mg; or a 10-mg check-weight might be used for … An analytical balance often used in the lab is the electronic balance. Press the key ‘ cal’ given in the front panel of the balance until the display of ‘Cal-int’ is displayed. This enclosure is often called a draft shield. 4) Never spill chemicals inside the analytical balance enclosure. Techniques for using an analytical balance. 5 Weighing-in aid A dynamic graphic indicator shows the used amount of the total weighing range. Procedure: * How to weigh out a sample of a solid for use in quantitative analysis. If there is any specific issue with the balance, you can refer to the troubleshooting section and follow the necessary steps. Temperatures of the balance and the material to be weighed should the same. Hi! Static charges have both a field component and a force component. Email: Handling of Rejected Raw and Packing Materials, Punches and Dies (Compression m/c) – Handling SOP, Cleaning and Sanitization in Pharmaceuticals, HPLC Calibration- A complete Guide – Part 2 of 3, SOP for Workplace During COVID-19 (Corona Virus), Cleaning of Pre-Filters, Microvee and Cartridge Filter, Acceptable Quality Level (AQL) – SOP and Chart, Non-Recoverable Recovery – Handling & Destruction, Purified Water Plant – Operation and Regeneration, SOP for material handling and movement (Procedure/Flow Chart), Analytical Method Validation (AMV) Procedure / Guide, Fire System – Operation and Maintenance SOP, Swab Test analysis of Equipment / Instrument – SOP, Sampling of Packaging Materials – Procedure, Roller Compactor Machine – Operation & Cleaning, Volumetric Solution – Preparation and Standardization. 0000001947 00000 n Every four readings (other than central reading) should lie in the range of ± 0.05% of central reading and actual mass value of weight. 2) The uncertainty of a reading made on the analytical balance is + 0.0001 g. 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